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Scientific Publications

Peer-reviewed preprints and patent filings — Open Access on Zenodo (CERN)

PatentOpen AccessZENODO · CERN

Epigenetic Scanner for Diagnosis and Command (E.S.D.C.)

Linchi (Lynch), Giorgio Sergio Carlo

November 2, 2025 — Preprint complementary to USPTO Provisional Patent Application

The ESDC is a conceptual platform integrating: (i) epigenetic maps based on multi-omic data; (ii) an epigenetic command module for safe, reversible molecular instructions; (iii) selective elimination of pathological tissues; and (iv) a pro-regenerative microenvironment. The goal is in-situ regeneration reducing reliance on transplantation.

Keywords: Epigenetics · OSK · Yamanaka Factors · Partial Reprogramming · CRISPR/dCas9 · AAV Vectors · Regenerative Medicine · Longevity

View on Zenodo DOI: 10.5281/zenodo.17506859

PreprintOpen AccessZENODO · CERN

Synchronization Strategy for Antioxidant and Cryoprotectant Action in the Ex-Vivo Liver

Linchi, Giorgio Sergio Carlo

October 26, 2025 — Concept Note for Integrated Perfusion and Remote Activation

A strategy for temporal synchronization of antioxidants and cryoprotectants in ex-vivo liver perfusion. The distribute-then-activate logic reduces oxidative and osmotic stress, improves CPA entry, and minimizes recrystallization during warming.

Keywords: Cryopreservation · Ex-Vivo Perfusion · Ice Recrystallization Inhibitors · Nanowarming · Regenerative Medicine

View on Zenodo DOI: 10.5281/zenodo.17445334

PreprintOpen AccessZENODO · CERN

ψ-One in Clinical Medicine: From Informational Entropy to Applications in Aging and Cardiology

Linchi, Giorgio Sergio Carlo

October 26, 2025 — English–Italian Edition

ψ-One is an entropic–informational framework quantifying the informational order of biological systems. It links Boltzmann's entropy with Shannon's informational entropy. Applications in cardiology include ischemic cardiomyopathy, heart failure, arrhythmias, and valvular diseases.

Keywords: Informational Entropy · Aging · Cardiology · ψ-One · Epigenetic Rejuvenation · OSK Reprogramming · Senolytics

View on Zenodo DOI: 10.5281/zenodo.17445169

All publications deposited on Zenodo, hosted by CERN. Each paper has a unique DOI for permanent citation.

Additional publications will be added as they become available.