Scientific Publications

Peer-reviewed research, patent filings, and scientific communications documenting Regenevia’s contributions to epigenetic science and regenerative medicine.

Published Research

Our research program is documented through a growing body of peer-reviewed publications, patent filings, and scientific communications. Below is a selection of key works that reflect the depth and direction of our scientific efforts.

USPTO Patent Portfolio

Five patent applications protecting our core innovations in epigenetic rejuvenation and regenerative medicine.

Patent 1

US Patent Application

Autologous 3D Micro-Tissue Generation System

Innovative system for generating personalized autologous serums using advanced 3D micro-tissue technology for regenerative medicine.

Patent 2

US Patent Application

System of Aging Reversal in an Adult Human Being

Comprehensive system for reversing biological aging through controlled epigenetic reprogramming.

Patent 3

US Patent Application

Personalized Autologous Serum Production

Method for producing personalized serums from patient’s own epithelial cells with patented molecular cocktail.

Patent 4

US Patent Application

Biologically Active Autologous Fillers

Advanced method for producing biologically active fillers yielding rich extracellular matrix with collagen, elastin, and HA.

Patent 5

US Patent Application

Genesis7 Systemic Bioactive Serum

Groundbreaking method for preparing systemic autologous bioactive serum for deep rejuvenation via IV infusion.

Book Publication

The Immortality Code

By Dr. Giorgio Sergio Carlo Lynch

A comprehensive exploration of epigenetic rejuvenation science, information theory applied to biological systems, and the new frontiers of human longevity. Includes the full text of the first USPTO patent for human rejuvenation.

Learn More

Scientific Communications

Zenodo Publications

Research papers and preprints published on the Zenodo open-access repository.

View on Zenodo →

Conference Presentations

Scientific presentations and posters at international conferences on epigenetics, regenerative medicine, and longevity research.

Technical Reports

Internal research reports and white papers documenting experimental results, protocol development, and translational progress.

Collaborate With Us

We welcome collaboration with academic institutions, research centers, and industry partners who share our commitment to rigorous, ethical science.

Contact Our Research Team

REGENEVIA BIO

Epigenetic Science & Cellular Reprogramming Research

Scientific Publications

Peer-reviewed preprints and patent filings — Open Access on Zenodo (CERN)

Patent Open Access ZENODO · CERN

Epigenetic Scanner for Diagnosis and Command (E.S.D.C.)

Linchi (Lynch), Giorgio Sergio Carlo

November 2, 2025 — Version 1.0 — Preprint complementary to USPTO Provisional Patent Application (2025)

The ESDC (Epigenetic Scanner for Diagnosis and Command) is a conceptual platform that integrates: (i) acquisition and modelling of epigenetic maps based on multi-omic and spatial data; (ii) an 'epigenetic command' module able to deliver safe and reversible molecular instructions; (iii) a selective elimination module to debulk pathological tissues; and (iv) a pro-regenerative microenvironment. We propose the composite index ψ-One to quantify the 'epigenetic order' of tissues and to steer therapeutic decisions with feedback. The goal is to enable in-situ regeneration while reducing reliance on transplantation and large-scale cell infusions.

Keywords: Epigenetics Maps · OSK · Yamanaka Factors · Partial Reprogramming · Epigenetic Clocks · DNA Methylation · CRISPR/dCas9 · AAV Vectors · Regenerative Medicine · Longevity · Tissue Regeneration

View on Zenodo DOI: 10.5281/zenodo.17506859

Preprint Open Access ZENODO · CERN

Synchronization Strategy for Antioxidant and Cryoprotectant Action in the Ex-Vivo Liver

Linchi, Giorgio Sergio Carlo

October 26, 2025 — Concept Note for Integrated Perfusion and Remote Activation

This concept note presents a strategy for the temporal synchronization of antioxidants and cryoprotectants in ex-vivo liver perfusion. By decoupling dose and timing, the approach enables homogeneous perfusion and simultaneous activation of antioxidants and ice recrystallization inhibitors through remote magneto-thermal or acoustic/photonic triggers. The "distribute-then-activate" logic reduces oxidative and osmotic stress, improves CPA entry, and minimizes recrystallization during warming, offering a scalable pathway for organ banking and nanowarming integration.

Keywords: Cryopreservation · Ex-Vivo Perfusion · Ice Recrystallization Inhibitors · Nanowarming · Regenerative Medicine

View on Zenodo DOI: 10.5281/zenodo.17445334

Preprint Open Access ZENODO · CERN

ψ-One in Clinical Medicine: From Informational Entropy to Applications in Aging and Cardiology

Linchi, Giorgio Sergio Carlo

October 26, 2025 — English–Italian Edition

ψ-One is an entropic–informational framework that quantifies the informational order of biological systems and its restoration through medical interventions. Rooted in the Linchi–Lynch Nova Theory and the Linchi–18 Relation, it links Boltzmann's physical entropy with Shannon's informational entropy, defining a measurable index of biological order. ψ-One provides clinicians and researchers with a unified metric to monitor entropy reduction in anti-aging and regenerative therapies, including partial OSK reprogramming, senolytics, and metabolic interventions. Applications in cardiology include ischemic cardiomyopathy, heart failure, arrhythmias, and valvular diseases, correlating ψ with ejection fraction, BNP, and heart rate variability.

Keywords: Informational Entropy · Aging · Cardiology · ψ-One · Epigenetic Rejuvenation · OSK Reprogramming · Senolytics · Regenerative Medicine

View on Zenodo DOI: 10.5281/zenodo.17445169

All publications are deposited on Zenodo, the open-access repository hosted by CERN (European Organization for Nuclear Research).
Each paper is assigned a unique Digital Object Identifier (DOI) for permanent citation and verification.

Additional publications will be added as they become available.

Scientific Publications

Peer-reviewed preprints and patent filings — Open Access on Zenodo (CERN)

PatentOpen AccessZENODO · CERN

Epigenetic Scanner for Diagnosis and Command (E.S.D.C.)

Linchi (Lynch), Giorgio Sergio Carlo

November 2, 2025 — Version 1.0 — Preprint complementary to USPTO Provisional Patent Application (2025)

The ESDC is a conceptual platform that integrates: (i) acquisition and modelling of epigenetic maps based on multi-omic and spatial data; (ii) an epigenetic command module able to deliver safe and reversible molecular instructions; (iii) a selective elimination module; and (iv) a pro-regenerative microenvironment. The goal is to enable in-situ regeneration while reducing reliance on transplantation.

Keywords: Epigenetics Maps · OSK · Yamanaka Factors · Partial Reprogramming · Epigenetic Clocks · DNA Methylation · CRISPR/dCas9 · AAV Vectors · Regenerative Medicine · Longevity

View on Zenodo DOI: 10.5281/zenodo.17506859

PreprintOpen AccessZENODO · CERN

Synchronization Strategy for Antioxidant and Cryoprotectant Action in the Ex-Vivo Liver

Linchi, Giorgio Sergio Carlo

October 26, 2025 — Concept Note for Integrated Perfusion and Remote Activation

This concept note presents a strategy for the temporal synchronization of antioxidants and cryoprotectants in ex-vivo liver perfusion. The distribute-then-activate logic reduces oxidative and osmotic stress, improves CPA entry, and minimizes recrystallization during warming.

Keywords: Cryopreservation · Ex-Vivo Perfusion · Ice Recrystallization Inhibitors · Nanowarming · Regenerative Medicine

View on Zenodo DOI: 10.5281/zenodo.17445334

PreprintOpen AccessZENODO · CERN

ψ-One in Clinical Medicine: From Informational Entropy to Applications in Aging and Cardiology

Linchi, Giorgio Sergio Carlo

October 26, 2025 — English–Italian Edition

ψ-One is an entropic–informational framework that quantifies the informational order of biological systems. It links Boltzmann's physical entropy with Shannon's informational entropy. Applications in cardiology include ischemic cardiomyopathy, heart failure, arrhythmias, and valvular diseases.

Keywords: Informational Entropy · Aging · Cardiology · ψ-One · Epigenetic Rejuvenation · OSK Reprogramming · Senolytics · Regenerative Medicine

View on Zenodo DOI: 10.5281/zenodo.17445169

All publications are deposited on Zenodo, the open-access repository hosted by CERN. Each paper is assigned a unique DOI for permanent citation.

Additional publications will be added as they become available.

The ESDC is a conceptual platform integrating: (i) epigenetic maps based on multi-omic data; (ii) an epigenetic command module for safe, reversible molecular instructions; (iii) selective elimination of pathological tissues; and (iv) a pro-regenerative microenvironment. The goal is in-situ regeneration reducing reliance on transplantation.

A strategy for temporal synchronization of antioxidants and cryoprotectants in ex-vivo liver perfusion. The distribute-then-activate logic reduces oxidative and osmotic stress, improves CPA entry, and minimizes recrystallization during warming.

ψ-One is an entropic–informational framework quantifying the informational order of biological systems. It links Boltzmann's entropy with Shannon's informational entropy. Applications in cardiology include ischemic cardiomyopathy, heart failure, arrhythmias, and valvular diseases.